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睡眠驅力來自於粒線體融合 - 修訂歷史
2026-05-06T03:51:37Z
本 Wiki 上此頁面的修訂歷史
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丁志仁 於 2025年12月9日 (二) 02:04
2025-12-09T02:04:05Z
<p></p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">←上個修訂</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">於 2025年12月9日 (二) 02:04 的修訂</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l1" >行 1：</td>
<td colspan="2" class="diff-lineno">行 1：</td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>[[分類:生命科學]]</div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>[[分類:生命科學<ins class="diffchange diffchange-inline">]][[分類:重磅材料</ins>]]</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div># 《Nature》雜誌 2025.7.16 發佈了題為《睡眠驅力來自於粒線體融合》（Mitochondrial origins of the pressure to sleep）的研究報告。</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div># 《Nature》雜誌 2025.7.16 發佈了題為《睡眠驅力來自於粒線體融合》（Mitochondrial origins of the pressure to sleep）的研究報告。</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div># <span style='vertical-align:top'>[https://www.youtube.com/@Jiu111 久不利多]製作的播客解說影片：(來源:[https://www.youtube.com/watch?v=mMgjlIC-VqQ Youtube])<embedvideo service='jendo' w='480' h='360'>http://urclass.net/files/wikiUsed/原來我們為了粒線體才需要睡覺！最新Nature研究.mp4</embedvideo></span></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div># <span style='vertical-align:top'>[https://www.youtube.com/@Jiu111 久不利多]製作的播客解說影片：(來源:[https://www.youtube.com/watch?v=mMgjlIC-VqQ Youtube])<embedvideo service='jendo' w='480' h='360'>http://urclass.net/files/wikiUsed/原來我們為了粒線體才需要睡覺！最新Nature研究.mp4</embedvideo></span></div></td></tr>
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丁志仁
http://well-being-ng.net/alWiki/index.php?title=%E7%9D%A1%E7%9C%A0%E9%A9%85%E5%8A%9B%E4%BE%86%E8%87%AA%E6%96%BC%E7%B2%92%E7%B7%9A%E9%AB%94%E8%9E%8D%E5%90%88&diff=8480&oldid=prev
丁志仁：/* 參考資料： */
2025-11-06T00:26:59Z
<p><span dir="auto"><span class="autocomment">參考資料：</span></span></p>
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<col class="diff-marker" />
<col class="diff-content" />
<col class="diff-marker" />
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<tr class="diff-title" lang="zh-Hant-TW">
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">←上個修訂</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">於 2025年11月6日 (四) 00:26 的修訂</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l146" >行 146：</td>
<td colspan="2" class="diff-lineno">行 146：</td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div># [[zhtwwikipedia::粒線體融合|粒線體融合]]</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div># [[zhtwwikipedia::粒線體融合|粒線體融合]]</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div># [http://urclass.net/files/wikiUsed/meuer.pdf 神經元凋亡過程中粒線體衰變的調控(德文)]，[https://ediss.uni-goettingen.de/bitstream/11858/00-1735-0000-0006-AC57-0/1/meuer.pdf 原文出處]，第10頁有粒線體被 Drp1 收縮致分裂的圖示</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div># [http://urclass.net/files/wikiUsed/meuer.pdf 神經元凋亡過程中粒線體衰變的調控(德文)]，[https://ediss.uni-goettingen.de/bitstream/11858/00-1735-0000-0006-AC57-0/1/meuer.pdf 原文出處]，第10頁有粒線體被 Drp1 收縮致分裂的圖示</div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div># [http://djqmfrancois.free.fr/AuP1complet/wp-content/uploads/NEMOS-Mitochondrie.pdf 粒線體](法文)</div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div># [http://djqmfrancois.free.fr/AuP1complet/wp-content/uploads/NEMOS-Mitochondrie.pdf 粒線體](法文)<ins class="diffchange diffchange-inline">，第5頁有粒線體被 Drp1 收縮致分裂的圖示</ins></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><h3>[https://www.nature.com Nature]</h3></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><h3>[https://www.nature.com Nature]</h3></div></td></tr>
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丁志仁
http://well-being-ng.net/alWiki/index.php?title=%E7%9D%A1%E7%9C%A0%E9%A9%85%E5%8A%9B%E4%BE%86%E8%87%AA%E6%96%BC%E7%B2%92%E7%B7%9A%E9%AB%94%E8%9E%8D%E5%90%88&diff=8479&oldid=prev
丁志仁：/* 參考資料： */
2025-11-06T00:23:03Z
<p><span dir="auto"><span class="autocomment">參考資料：</span></span></p>
<table class="diff diff-contentalign-left diff-editfont-monospace" data-mw="interface">
<col class="diff-marker" />
<col class="diff-content" />
<col class="diff-marker" />
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<tr class="diff-title" lang="zh-Hant-TW">
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">←上個修訂</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">於 2025年11月6日 (四) 00:23 的修訂</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l145" >行 145：</td>
<td colspan="2" class="diff-lineno">行 145：</td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div># [http://jendo.org/files/wikiUsed/Mitochondrial%20origins%20of%20the%20pressure%20to%20sleep.pdf 報告]，[https://www.nature.com/articles/s41586-025-09261-y.pdf Nature 官網下載點]</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div># [http://jendo.org/files/wikiUsed/Mitochondrial%20origins%20of%20the%20pressure%20to%20sleep.pdf 報告]，[https://www.nature.com/articles/s41586-025-09261-y.pdf Nature 官網下載點]</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div># [[zhtwwikipedia::粒線體融合|粒線體融合]]</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div># [[zhtwwikipedia::粒線體融合|粒線體融合]]</div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div># [http://urclass.net/files/wikiUsed/meuer.pdf 神經元凋亡過程中粒線體衰變的調控(德文)]，[https://ediss.uni-goettingen.de/bitstream/11858/00-1735-0000-0006-AC57-0/1/meuer.pdf 原文出處]<del class="diffchange diffchange-inline">，P10 有粒線體被 </del>Drp1 收縮致分裂的圖示</div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div># [http://urclass.net/files/wikiUsed/meuer.pdf 神經元凋亡過程中粒線體衰變的調控(德文)]，[https://ediss.uni-goettingen.de/bitstream/11858/00-1735-0000-0006-AC57-0/1/meuer.pdf 原文出處]<ins class="diffchange diffchange-inline">，第10頁有粒線體被 </ins>Drp1 收縮致分裂的圖示</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div># [http://djqmfrancois.free.fr/AuP1complet/wp-content/uploads/NEMOS-Mitochondrie.pdf 粒線體](法文)</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div># [http://djqmfrancois.free.fr/AuP1complet/wp-content/uploads/NEMOS-Mitochondrie.pdf 粒線體](法文)</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
</table>
丁志仁
http://well-being-ng.net/alWiki/index.php?title=%E7%9D%A1%E7%9C%A0%E9%A9%85%E5%8A%9B%E4%BE%86%E8%87%AA%E6%96%BC%E7%B2%92%E7%B7%9A%E9%AB%94%E8%9E%8D%E5%90%88&diff=8478&oldid=prev
丁志仁：/* 參考資料： */
2025-11-06T00:21:51Z
<p><span dir="auto"><span class="autocomment">參考資料：</span></span></p>
<table class="diff diff-contentalign-left diff-editfont-monospace" data-mw="interface">
<col class="diff-marker" />
<col class="diff-content" />
<col class="diff-marker" />
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">←上個修訂</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">於 2025年11月6日 (四) 00:21 的修訂</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l145" >行 145：</td>
<td colspan="2" class="diff-lineno">行 145：</td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div># [http://jendo.org/files/wikiUsed/Mitochondrial%20origins%20of%20the%20pressure%20to%20sleep.pdf 報告]，[https://www.nature.com/articles/s41586-025-09261-y.pdf Nature 官網下載點]</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div># [http://jendo.org/files/wikiUsed/Mitochondrial%20origins%20of%20the%20pressure%20to%20sleep.pdf 報告]，[https://www.nature.com/articles/s41586-025-09261-y.pdf Nature 官網下載點]</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div># [[zhtwwikipedia::粒線體融合|粒線體融合]]</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div># [[zhtwwikipedia::粒線體融合|粒線體融合]]</div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"># [http://urclass.net/files/wikiUsed/meuer.pdf 神經元凋亡過程中粒線體衰變的調控(德文)]，[https://ediss.uni-goettingen.de/bitstream/11858/00-1735-0000-0006-AC57-0/1/meuer.pdf 原文出處]，P10 有粒線體被 Drp1 收縮致分裂的圖示</ins></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div># [http://djqmfrancois.free.fr/AuP1complet/wp-content/uploads/NEMOS-Mitochondrie.pdf 粒線體](法文)</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div># [http://djqmfrancois.free.fr/AuP1complet/wp-content/uploads/NEMOS-Mitochondrie.pdf 粒線體](法文)</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
</table>
丁志仁
http://well-being-ng.net/alWiki/index.php?title=%E7%9D%A1%E7%9C%A0%E9%A9%85%E5%8A%9B%E4%BE%86%E8%87%AA%E6%96%BC%E7%B2%92%E7%B7%9A%E9%AB%94%E8%9E%8D%E5%90%88&diff=8477&oldid=prev
丁志仁：/* 參考資料： */
2025-11-05T16:51:33Z
<p><span dir="auto"><span class="autocomment">參考資料：</span></span></p>
<table class="diff diff-contentalign-left diff-editfont-monospace" data-mw="interface">
<col class="diff-marker" />
<col class="diff-content" />
<col class="diff-marker" />
<col class="diff-content" />
<tr class="diff-title" lang="zh-Hant-TW">
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">←上個修訂</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">於 2025年11月5日 (三) 16:51 的修訂</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l145" >行 145：</td>
<td colspan="2" class="diff-lineno">行 145：</td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div># [http://jendo.org/files/wikiUsed/Mitochondrial%20origins%20of%20the%20pressure%20to%20sleep.pdf 報告]，[https://www.nature.com/articles/s41586-025-09261-y.pdf Nature 官網下載點]</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div># [http://jendo.org/files/wikiUsed/Mitochondrial%20origins%20of%20the%20pressure%20to%20sleep.pdf 報告]，[https://www.nature.com/articles/s41586-025-09261-y.pdf Nature 官網下載點]</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div># [[zhtwwikipedia::粒線體融合|粒線體融合]]</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div># [[zhtwwikipedia::粒線體融合|粒線體融合]]</div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"># [http://djqmfrancois.free.fr/AuP1complet/wp-content/uploads/NEMOS-Mitochondrie.pdf 粒線體](法文)</ins></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><h3>[https://www.nature.com Nature]</h3></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><h3>[https://www.nature.com Nature]</h3></div></td></tr>
<tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l200" >行 200：</td>
<td colspan="2" class="diff-lineno">行 201：</td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div># <span style='vertical-align:top'>真菌粒線體和過氧化物酶體的分裂。<br/>(a) 粒線體的排列是由動力蛋白介導的融合和分裂事件決定。融合分別由位於粒線體外膜和內膜的動力蛋白Fzo1（粒線體融合蛋白）和Mgm1（Opa1）驅動，而Dnm1則介導分裂。<br/>(b) 過氧化物酶體透過從已存在的細胞器生長和分裂而增殖，此過程也涉及Dnm1。 Dnm1透過與Mdv1銜接蛋白（下圖）的相互作用，被膜受體Fis1募集到粒線體和過氧化物酶體。隨後，Dnm1在細胞器周圍組裝成螺旋狀結構，並在GTP水解時收縮並切斷細胞器膜。過氧化物酶體的分裂之前是細胞器的伸長，而細胞器的伸長是由膜伸長因子Pex11促進的。該蛋白質也可作為 Dnm1 活化劑。<img src='http://urclass.net/files/wikiUsed/Mitochondrial-and-peroxisome-division-in-fungi-a-The-mitochondrial-arrangement-is.png'/></span></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div># <span style='vertical-align:top'>真菌粒線體和過氧化物酶體的分裂。<br/>(a) 粒線體的排列是由動力蛋白介導的融合和分裂事件決定。融合分別由位於粒線體外膜和內膜的動力蛋白Fzo1（粒線體融合蛋白）和Mgm1（Opa1）驅動，而Dnm1則介導分裂。<br/>(b) 過氧化物酶體透過從已存在的細胞器生長和分裂而增殖，此過程也涉及Dnm1。 Dnm1透過與Mdv1銜接蛋白（下圖）的相互作用，被膜受體Fis1募集到粒線體和過氧化物酶體。隨後，Dnm1在細胞器周圍組裝成螺旋狀結構，並在GTP水解時收縮並切斷細胞器膜。過氧化物酶體的分裂之前是細胞器的伸長，而細胞器的伸長是由膜伸長因子Pex11促進的。該蛋白質也可作為 Dnm1 活化劑。<img src='http://urclass.net/files/wikiUsed/Mitochondrial-and-peroxisome-division-in-fungi-a-The-mitochondrial-arrangement-is.png'/></span></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>#*[https://www.researchgate.net/figure/Mitochondrial-and-peroxisome-division-in-fungi-a-The-mitochondrial-arrangement-is_fig1_347068284 圖示來源 researchgate]</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>#*[https://www.researchgate.net/figure/Mitochondrial-and-peroxisome-division-in-fungi-a-The-mitochondrial-arrangement-is_fig1_347068284 圖示來源 researchgate]</div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"># [http://djqmfrancois.free.fr/AuP1complet/wp-content/uploads/NEMOS-Mitochondrie.pdf 粒線體](法文)</del></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div># 相關蛋白質名稱對照表：<table class='nicetable'></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div># 相關蛋白質名稱對照表：<table class='nicetable'></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><tr><th>功能</th><th>哺乳類(mammal)</th><th>酵母(yeast)</th><th>果蠅(Drosophila)</th></tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><tr><th>功能</th><th>哺乳類(mammal)</th><th>酵母(yeast)</th><th>果蠅(Drosophila)</th></tr></div></td></tr>
</table>
丁志仁
http://well-being-ng.net/alWiki/index.php?title=%E7%9D%A1%E7%9C%A0%E9%A9%85%E5%8A%9B%E4%BE%86%E8%87%AA%E6%96%BC%E7%B2%92%E7%B7%9A%E9%AB%94%E8%9E%8D%E5%90%88&diff=8476&oldid=prev
丁志仁：/* 參考資料： */
2025-11-05T16:49:32Z
<p><span dir="auto"><span class="autocomment">參考資料：</span></span></p>
<table class="diff diff-contentalign-left diff-editfont-monospace" data-mw="interface">
<col class="diff-marker" />
<col class="diff-content" />
<col class="diff-marker" />
<col class="diff-content" />
<tr class="diff-title" lang="zh-Hant-TW">
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">←上個修訂</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">於 2025年11月5日 (三) 16:49 的修訂</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l206" >行 206：</td>
<td colspan="2" class="diff-lineno">行 206：</td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><tr><td>融合 fusion：外膜(OMM)</td><td><strong>Mfn1 / Mfn2</strong></td><td><strong>Fzo1</strong></td><td><strong>Marf</strong></td></tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><tr><td>融合 fusion：外膜(OMM)</td><td><strong>Mfn1 / Mfn2</strong></td><td><strong>Fzo1</strong></td><td><strong>Marf</strong></td></tr></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><tr><td>融合 fusion：內膜(IMM)</td><td><strong>Opa1</strong></td><td><strong>Mgm1</strong></td><td>'''Opa1'''</td></tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><tr><td>融合 fusion：內膜(IMM)</td><td><strong>Opa1</strong></td><td><strong>Mgm1</strong></td><td>'''Opa1'''</td></tr></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div></table><table class='nicetable'></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div></table<ins class="diffchange diffchange-inline">><br/</ins>><table class='nicetable'></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><tr><th>構件</th><th>職務簡稱</th><th>模式生物</th></tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><tr><th>構件</th><th>職務簡稱</th><th>模式生物</th></tr></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><tr><td>Fis1</td><td>外膜錨點、把 fission 複合體釘在外膜</td><td>酵母(yeast)</td></tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><tr><td>Fis1</td><td>外膜錨點、把 fission 複合體釘在外膜</td><td>酵母(yeast)</td></tr></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><tr><td>Mdv1</td><td>幫 Dnm1 過來 → 固定 → 組圈圈</td><td>酵母(yeast)</td></tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><tr><td>Mdv1</td><td>幫 Dnm1 過來 → 固定 → 組圈圈</td><td>酵母(yeast)</td></tr></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div></table></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div></table></div></td></tr>
</table>
丁志仁
http://well-being-ng.net/alWiki/index.php?title=%E7%9D%A1%E7%9C%A0%E9%A9%85%E5%8A%9B%E4%BE%86%E8%87%AA%E6%96%BC%E7%B2%92%E7%B7%9A%E9%AB%94%E8%9E%8D%E5%90%88&diff=8475&oldid=prev
丁志仁：/* 參考資料： */
2025-11-05T16:48:49Z
<p><span dir="auto"><span class="autocomment">參考資料：</span></span></p>
<table class="diff diff-contentalign-left diff-editfont-monospace" data-mw="interface">
<col class="diff-marker" />
<col class="diff-content" />
<col class="diff-marker" />
<col class="diff-content" />
<tr class="diff-title" lang="zh-Hant-TW">
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">←上個修訂</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">於 2025年11月5日 (三) 16:48 的修訂</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l206" >行 206：</td>
<td colspan="2" class="diff-lineno">行 206：</td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><tr><td>融合 fusion：外膜(OMM)</td><td><strong>Mfn1 / Mfn2</strong></td><td><strong>Fzo1</strong></td><td><strong>Marf</strong></td></tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><tr><td>融合 fusion：外膜(OMM)</td><td><strong>Mfn1 / Mfn2</strong></td><td><strong>Fzo1</strong></td><td><strong>Marf</strong></td></tr></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><tr><td>融合 fusion：內膜(IMM)</td><td><strong>Opa1</strong></td><td><strong>Mgm1</strong></td><td>'''Opa1'''</td></tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><tr><td>融合 fusion：內膜(IMM)</td><td><strong>Opa1</strong></td><td><strong>Mgm1</strong></td><td>'''Opa1'''</td></tr></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></table><table class='nicetable'></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"><tr><th>構件</th><th>職務簡稱</th><th>模式生物</th></tr></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"><tr><td>Fis1</td><td>外膜錨點、把 fission 複合體釘在外膜</td><td>酵母(yeast)</td></tr></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"><tr><td>Mdv1</td><td>幫 Dnm1 過來 → 固定 → 組圈圈</td><td>酵母(yeast)</td></tr></ins></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div></table></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div></table></div></td></tr>
</table>
丁志仁
http://well-being-ng.net/alWiki/index.php?title=%E7%9D%A1%E7%9C%A0%E9%A9%85%E5%8A%9B%E4%BE%86%E8%87%AA%E6%96%BC%E7%B2%92%E7%B7%9A%E9%AB%94%E8%9E%8D%E5%90%88&diff=8474&oldid=prev
丁志仁：/* 參考資料： */
2025-11-05T16:28:17Z
<p><span dir="auto"><span class="autocomment">參考資料：</span></span></p>
<table class="diff diff-contentalign-left diff-editfont-monospace" data-mw="interface">
<col class="diff-marker" />
<col class="diff-content" />
<col class="diff-marker" />
<col class="diff-content" />
<tr class="diff-title" lang="zh-Hant-TW">
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">←上個修訂</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">於 2025年11月5日 (三) 16:28 的修訂</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l203" >行 203：</td>
<td colspan="2" class="diff-lineno">行 203：</td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div># 相關蛋白質名稱對照表：<table class='nicetable'></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div># 相關蛋白質名稱對照表：<table class='nicetable'></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><tr><th>功能</th><th>哺乳類(mammal)</th><th>酵母(yeast)</th><th>果蠅(Drosophila)</th></tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><tr><th>功能</th><th>哺乳類(mammal)</th><th>酵母(yeast)</th><th>果蠅(Drosophila)</th></tr></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><tr><td>分裂(fission)</td><td><strong>Drp1 / DNM1L</strong></td><td><strong>Dnm1</strong></td><td>Drp1(也有人稱 Drp1-like)</td></tr></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><tr><td>分裂(fission)</td><td><strong>Drp1 / DNM1L</strong></td><td><strong>Dnm1</strong></td><td><ins class="diffchange diffchange-inline">'''</ins>Drp1<ins class="diffchange diffchange-inline">'''</ins>(也有人稱 Drp1-like)</td></tr></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><tr><td>融合 fusion：外膜(OMM)</td><td><strong>Mfn1 / Mfn2</strong></td><td><strong>Fzo1</strong></td><td><strong>Marf</strong></td></tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><tr><td>融合 fusion：外膜(OMM)</td><td><strong>Mfn1 / Mfn2</strong></td><td><strong>Fzo1</strong></td><td><strong>Marf</strong></td></tr></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><tr><td>融合 fusion：內膜(IMM)</td><td><strong>Opa1</strong></td><td><strong>Mgm1</strong></td><td>Opa1</td></tr></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><tr><td>融合 fusion：內膜(IMM)</td><td><strong>Opa1</strong></td><td><strong>Mgm1</strong></td><td><ins class="diffchange diffchange-inline">'''</ins>Opa1<ins class="diffchange diffchange-inline">'''</ins></td></tr></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div></table></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div></table></div></td></tr>
</table>
丁志仁
http://well-being-ng.net/alWiki/index.php?title=%E7%9D%A1%E7%9C%A0%E9%A9%85%E5%8A%9B%E4%BE%86%E8%87%AA%E6%96%BC%E7%B2%92%E7%B7%9A%E9%AB%94%E8%9E%8D%E5%90%88&diff=8473&oldid=prev
丁志仁：/* 參考資料： */
2025-11-05T16:25:46Z
<p><span dir="auto"><span class="autocomment">參考資料：</span></span></p>
<table class="diff diff-contentalign-left diff-editfont-monospace" data-mw="interface">
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<col class="diff-content" />
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<col class="diff-content" />
<tr class="diff-title" lang="zh-Hant-TW">
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">←上個修訂</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">於 2025年11月5日 (三) 16:25 的修訂</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l201" >行 201：</td>
<td colspan="2" class="diff-lineno">行 201：</td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>#*[https://www.researchgate.net/figure/Mitochondrial-and-peroxisome-division-in-fungi-a-The-mitochondrial-arrangement-is_fig1_347068284 圖示來源 researchgate]</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>#*[https://www.researchgate.net/figure/Mitochondrial-and-peroxisome-division-in-fungi-a-The-mitochondrial-arrangement-is_fig1_347068284 圖示來源 researchgate]</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div># [http://djqmfrancois.free.fr/AuP1complet/wp-content/uploads/NEMOS-Mitochondrie.pdf 粒線體](法文)</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div># [http://djqmfrancois.free.fr/AuP1complet/wp-content/uploads/NEMOS-Mitochondrie.pdf 粒線體](法文)</div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"># 相關蛋白質名稱對照表：<table class='nicetable'></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"><tr><th>功能</th><th>哺乳類(mammal)</th><th>酵母(yeast)</th><th>果蠅(Drosophila)</th></tr></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"><tr><td>分裂(fission)</td><td><strong>Drp1 / DNM1L</strong></td><td><strong>Dnm1</strong></td><td>Drp1(也有人稱 Drp1-like)</td></tr></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"><tr><td>融合 fusion：外膜(OMM)</td><td><strong>Mfn1 / Mfn2</strong></td><td><strong>Fzo1</strong></td><td><strong>Marf</strong></td></tr></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"><tr><td>融合 fusion：內膜(IMM)</td><td><strong>Opa1</strong></td><td><strong>Mgm1</strong></td><td>Opa1</td></tr></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></table></ins></div></td></tr>
</table>
丁志仁
http://well-being-ng.net/alWiki/index.php?title=%E7%9D%A1%E7%9C%A0%E9%A9%85%E5%8A%9B%E4%BE%86%E8%87%AA%E6%96%BC%E7%B2%92%E7%B7%9A%E9%AB%94%E8%9E%8D%E5%90%88&diff=8472&oldid=prev
丁志仁 於 2025年11月5日 (三) 16:15
2025-11-05T16:15:11Z
<p></p>
<table class="diff diff-contentalign-left diff-editfont-monospace" data-mw="interface">
<col class="diff-marker" />
<col class="diff-content" />
<col class="diff-marker" />
<col class="diff-content" />
<tr class="diff-title" lang="zh-Hant-TW">
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">←上個修訂</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">於 2025年11月5日 (三) 16:15 的修訂</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l106" >行 106：</td>
<td colspan="2" class="diff-lineno">行 106：</td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>至此，我們已經有了一條清晰的邏輯鏈：清醒 → dFBNs 被抑制 → ATP 消耗降低 → 電子在 ETC 中「堵車」 → 電子溢出產生 ROS → 線粒體受損併發生分裂（碎片化）。現在，我們面臨最後一個，也是最核心的問題：線粒體的這種形態變化，是如何最終轉化為控制整個機體睡眠行為的命令的？</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>至此，我們已經有了一條清晰的邏輯鏈：清醒 → dFBNs 被抑制 → ATP 消耗降低 → 電子在 ETC 中「堵車」 → 電子溢出產生 ROS → 線粒體受損併發生分裂（碎片化）。現在，我們面臨最後一個，也是最核心的問題：線粒體的這種形態變化，是如何最終轉化為控制整個機體睡眠行為的命令的？</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>線粒體的形態並非一成不變，而是在分裂 (fission) 和融合 (fusion) 之間進行著動態的平衡之舞。這個舞蹈由一組特殊的 GTP 酶家族蛋白精確調控。其中，Drp1 蛋白是分裂的主要執行者，它像一個項圈一樣，箍線上粒體上並收緊，最終將其「掐斷」。而 Marf 和 <del class="diffchange diffchange-inline">Opal </del>蛋白則是融合的關鍵角色，它們分別負責線粒體外膜和內膜的融合，讓兩個線粒體合併成一個。</div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>線粒體的形態並非一成不變，而是在分裂 (fission) 和融合 (fusion) 之間進行著動態的平衡之舞。這個舞蹈由一組特殊的 GTP 酶家族蛋白精確調控。其中，Drp1 蛋白是分裂的主要執行者，它像一個項圈一樣，箍線上粒體上並收緊，最終將其「掐斷」。而 Marf 和 <ins class="diffchange diffchange-inline">Opa1 </ins>蛋白則是融合的關鍵角色，它們分別負責線粒體外膜和內膜的融合，讓兩個線粒體合併成一個。</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>研究人員猜測，這場「分合之舞」本身，可能就是調節睡眠的「舞步」。如果說線粒體分裂是機體應對睡眠壓力（即電子溢出和損傷）的一種應答，那麼人為地操縱這個過程，應該也能影響睡眠。他們再次動用了基因「手術刀」，在 dFBNs 中強制改變這場舞蹈的節奏。</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>研究人員猜測，這場「分合之舞」本身，可能就是調節睡眠的「舞步」。如果說線粒體分裂是機體應對睡眠壓力（即電子溢出和損傷）的一種應答，那麼人為地操縱這個過程，應該也能影響睡眠。他們再次動用了基因「手術刀」，在 dFBNs 中強制改變這場舞蹈的節奏。</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>當強制分裂時：他們過量表達了分裂蛋白 Drp1，或者敲低了融合蛋白 Marf/<del class="diffchange diffchange-inline">Opal。這相當於讓線粒體持續處於碎片化的狀態，模擬的是機體已經「還完睡眠債」並開始修復的訊號。結果出人意料卻又在情理之中：這些果蠅的睡眠時間顯著減少了，並且在睡眠剝奪后幾乎沒有睡眠反彈。這說明，線粒體分裂這個動作，本身就是一種「睡眠壓力已釋放」的訊號。通過人為製造這個訊號，系統被「欺騙」了，認為不再需要睡眠。</del></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>當強制分裂時：他們過量表達了分裂蛋白 Drp1，或者敲低了融合蛋白 Marf/<ins class="diffchange diffchange-inline">Opa1。這相當於讓線粒體持續處於碎片化的狀態，模擬的是機體已經「還完睡眠債」並開始修復的訊號。結果出人意料卻又在情理之中：這些果蠅的睡眠時間顯著減少了，並且在睡眠剝奪后幾乎沒有睡眠反彈。這說明，線粒體分裂這個動作，本身就是一種「睡眠壓力已釋放」的訊號。通過人為製造這個訊號，系統被「欺騙」了，認為不再需要睡眠。</ins></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>當強制融合時：反過來，他們敲低了分裂蛋白 Drp1，或者過量表達了融合蛋白 Marf 和 <del class="diffchange diffchange-inline">Opal。這讓線粒體無法正常分裂，即使在電子溢出和 </del>ROS 損傷不斷累積的情況下，它們也只能「硬扛」，無法啟動修復程式。結果與強制分裂完全相反：這些果蠅的睡眠時間大大增加，睡得更沉，更難被喚醒。這表明，當「壓力釋放」的訊號通路（即線粒體分裂）被阻斷時，睡眠壓力會以前所未有的程度累積，導致機體需要更長、更深的睡眠來償還這筆「巨額債務」。</div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>當強制融合時：反過來，他們敲低了分裂蛋白 Drp1，或者過量表達了融合蛋白 Marf 和 <ins class="diffchange diffchange-inline">Opa1。這讓線粒體無法正常分裂，即使在電子溢出和 </ins>ROS 損傷不斷累積的情況下，它們也只能「硬扛」，無法啟動修復程式。結果與強制分裂完全相反：這些果蠅的睡眠時間大大增加，睡得更沉，更難被喚醒。這表明，當「壓力釋放」的訊號通路（即線粒體分裂）被阻斷時，睡眠壓力會以前所未有的程度累積，導致機體需要更長、更深的睡眠來償還這筆「巨額債務」。</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>這些實驗的結果，將線粒體的形態動態與睡眠行為直接掛鉤。但最終的聯繫點在哪裡？答案是神經元的電生理特性 (electrophysiological properties)。研究人員通過活體腦片電生理記錄，直接分析了不同狀態下 dFBNs 的「興奮性」。他們發現，線粒體的形態直接決定了神經元的放電能力：</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>這些實驗的結果，將線粒體的形態動態與睡眠行為直接掛鉤。但最終的聯繫點在哪裡？答案是神經元的電生理特性 (electrophysiological properties)。研究人員通過活體腦片電生理記錄，直接分析了不同狀態下 dFBNs 的「興奮性」。他們發現，線粒體的形態直接決定了神經元的放電能力：</div></td></tr>
</table>
丁志仁